A new opinion article about the challenges in distinguishing functional proteins from polyproteins in databases
Challenges in distinguishing functional proteins from polyproteins in databases: implications for drug discovery
We have published an opinion letter about the challenges in distinguishing functional proteins from polyproteins in databases. To solve this issue, UniProt now employs a feature identifier to provide a unique and stable identifier for each of the proteins derived from a polyprotein. However, some databases have not yet implemented an effective solution, making it difficult to collect data specific to these proteins and potentially leading to manual curation errors.
Llop-Peiró A, Pujadas G, Garcia-Vallvé S. Challenges in distinguishing functional proteins from polyproteins in databases: implications for drug discovery. Brief Bioinform. 2024 Jan 22;25(2):bbae012. doi: 10.1093/bib/bbae012.
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